Cronos Colondrain, Biologically Active Food Supplement, is a preparation based on Triphala, a well-recognized and revered polyherbal Indian ayurvedic medical preparation consisting of dried fruits of the three plant species Emblica officinalis (Family Euphorbiaceae), Terminalia bellerica (Family Combretaceae), and Terminalia chebula (Family Combretaceae) together with Artichoke extract, useful in all cases of reduced dietary intake or increased need for useful components to improve gastrointestinal health and promotes efficient digestion, absorption, elimination, and rejuvenation.
A tablet of Cronos Colondrain is able to supply 750 mg of Triphala and 150 mg of Artichoke extract . The particularly balanced formulation seems to play a positive role in the psycho-physical balance, with plants of proven activity and great tradition such as Triphala polyherbal and artichoke extract of improving the gastrointestinal health and to help in the case of constipation, abdominal pain, hyperacidity, and flatulence stimulating beneficial gut bacteria and liver’s health.
Deregulation of eating behaviors common in industrialized countries. One of the main problems, related to unbalanced food based on hulled and extremely refined foods is the proliferation of intestinal pathogenic bacteria and yeasts that promotes the development of colitis and enteritis (respectively inflammation of the colon and inflammation of the first part of the intestine). Furthermore, if the waste material is allowed to stagnate in the colon, a process of putrefaction will begin that will irritate the mucosa, making it more permeable to toxic substances that will enter the bloodstream. The process causes the degradation of the intestinal mucosa with the alteration of the bacterial flora.
Triphala consists of fruits of the plant species Emblica officinalis (Amalaki), Terminalia bellerica (Bibhitaki), and Terminalia chebula (Haritaki) in equal proportions and has been used in traditional medicine in India for centuries. Triphala helps purify toxins from the body. It also does this by strengthening and stimulating the liver and helps elimination and helps relieve constipation.The ingredients that make up Triphala are powerful individually. When combined correctly, synergy enhances the healing quotient exponentially.
The major constituents of Triphala are the tannins, gallic acid, ellagic acid, and chebulinic acid, which are potent antioxidants that may account, at least in part, for the observed immunomodulatory activity of the formula. Triphala also contains other bioactive compounds such as flavonoids (quercetin and luteolin), saponins, anthraquinones, amino acids, fatty acids, and various carbohydrates4. In addition, Triphala derived polyphenols such as chebulinic acid are also transformed by the human gut microbiota into bioactive metabolites, which have demonstrated potential in vitro to prevent oxidative damage. Amalaki is an excellent source of Vitamin C, and is the most concentrated and absorbable source of the vitamin in the plant kingdom.
Artichoke is considered a functional food due to its high content of phenolic compounds and inulin. The main compounds are caffeoylquinic acids, mono and dicaffeoylquinic acids and the most abundant are chlorogenic acid and 1,5-dicaffeoylquinic acid. Moreover flavones glycosides represent another important class and the major compounds are luteolin-7-O-rutinoside and apigenin-7-O-glucoside. Artichoke has been used in folk medicine against liver and gallbladder complaints and leaves extracts have been used as hepatoprotective, choleretic and lipid-lowering agents. The beneficial and therapeutic activity can be ascribed mainly to presence of caffeoylquinic acids and flavones.
For the first time a preparation based on this combination of herbs and active ingredients in a mixture is proposed and marketed.
Artichoke has been used in folk medicine against liver and gallbladder complaints and leaves extracts have been used as hepatoprotective, choleretic and lipid-lowering agents. The beneficial and therapeutic activity can be ascribed mainly to presence of caffeoylquinic acids and flavones. Furthermore edible portion of artichoke is a great resource of inulin (18-36% dry matter), a reserve carbohydrate with specific prebiotic properties. Several studies suggest that the hepatoprotective effect of artichoke extracts are due to their antioxidant activity. Artichoke leaf extracts showed antioxidant action against hydroperoxide-induced oxidative stress in cultured rat hepatocytes, human hepatoma HepG2 cells and human leukocytes, and chlorogenic acid and cynarin accounted for part of this activity.
Gastrointestinal health. Triphala is perhaps most well known for its use in general gastrointestinal health. Animal studies have shown that both aqueous and alcohol-based extracts of Triphala prevent diarrhea. Triphala also induces enteroprotective effects, which are likely due, at least in part, to the high antioxidant content. In a rodent model, Triphala replenished depleted protein in the intestinal villi of the brush border as well as glutathione and phospholipid levels; the formula simultaneously decreased myeloperoxidase and xanthineoxidase levels in intestinal epithelium. In rats, Triphala exerted a gastroprotective effect on stress-induced ulcer. One human clinical trial that investigated the use of Triphala in patients with gastrointestinal disorders reported that treatment reduced constipation, mucous, abdominal pain, hyperacidity, and flatulence while improving the frequency, yield, and consistency of stool.Triphala also reduced colitis in a mouse model, and the treatment effect was attributed to antioxidant effects and high levels of flavonoids contained in Triphala.
Antiobesogenic potential of Triphala. Studies have demonstrated the potential of Triphala as a therapeutic agent for weight loss and reduction of body fat. In an animal study, Triphala was administered for 10 weeks to diet-induced obese mice. Triphala treatment decreased the percentage of body fat, body weight, and energy intake. Triphala also decreased total cholesterol, triglycerides, and low-density lipoprotein cholesterol in the experimental group compared with the control group. In a 12-week, double-blind, randomized placebo-controlled trial, human subjects treated with Triphala lost∼5 kg compared with the placebo control group. Mean fasting blood sugar and fasting serum insulin levels were also reduced in the treated compared with control subjects. Given the global obesity epidemic, more treatment options are necessary to reduce the associated health care burden.
Antidiabetic activity. Triphala exerts hypoglycemic effects. Patients with type 2 diabetes are likely to have high postprandial blood glucose levels, especially after consuming carbohydrates. Past studies report that Triphala may exert actions similar to diabetic pharmaceutical drugs, such as miglitol and acarbose, by inhibiting digestive enzymes and may decrease absorption of glucose through inhibition of glycolytic enzymes, there by reducing blood glucose levels. One study demonstrated the inhibitory potential of Triphala on pancreatic glycolytic enzymes, namely alpha-amylase and alpha-glucosidase, which break down larger polysaccharides into glucose molecules that enter the blood stream.
A clinical study of noninsulin-dependent diabetes mellitus patients revealed that supplementation with 5 g of Triphala powder for 45 days significantly lowered blood glucose levels. Both fasting and postprandial blood glucose were reduced, which may be due to active ingredients such as sorbitol. Constituents in Triphala, including ellagitannins and gallotannins, also enhance both PPAR-alpha and -gamma signaling, which increase insulin responsiveness and glucose uptake without inducing adipogenesis. These polyphenols may also promote decreased blood glucose and insulin levels in diabetic patients.
- Cancer prevention
- Colon cleanser
- Intestine regulator
- Weight loss
- Lower cholesterol
- Improve bone and cartilage breakdown
- Natural laxative
- Hypoglycemic agent