Cronos DE:TOX, Biologically Active phytotherapic complex, with draining (orthosiphon, dandelion and Polyporus), cardiotonic (hawthorn), antioxidant and detox (sylimarin and quercetin) metabolic (orthosiphon, quercetin, chromium). The particularly balanced formulation promote the depurative physiological process in the body, improve circulation and restore well-being to legs.
Two capsules a day of Cronos DE:TOX, promote the physiological process of purification in the body and is particularly indicated in the prevention and treatment of the pathophysiology of water retention, in the prevention and treatment of cellulite, in obese and overweight patients in a restrictive diet regimen as it activates lipid catabolism.
Cronos DE:TOX is useful in all the low-calorie diets, such as the oloproteic diet and the integrated dissociated diet, reducing insulin resistance and stimulating insulin sensitivity.
Lymphatic leakage can be seen as a detrimental phenomenon associated with fluid retention and deposition as well as gain of weight. Moreover, lymphatic dysfunction is associated with an inflammatory environment and can be a substrate for other health conditions. A number of treatments can ameliorate lymphatic vasculature: natural substances have been used as treatment options particularly suitable for their consolidated effectiveness and safety profile. Cronos DE:TOX, an association of a series of plant-derived natural complexes would be useful to ameliorate conditions of altered lymphatic vasculature and to support the physiological functionality of the lymphatic endothelium, naturally counteracting water retention and helping to keep your legs and body fit and in perfect health.
The presence of cellulite is an aesthetically unacceptable cosmetic problem for most post‐adolescent women. It is largely observed in the gluteal‐fermoral regions with its ‘orange‐peel’ or ‘cottage cheese’ appearance. It is not specific to overweight women although increased adipogenicity will exacerbate the condition. It is a complex problem involving the microcirculatory system and lymphatics, the extracellular matrix and the presence of excess subcutaneous fat that bulges into the dermis. It is necessary to make a distinction between those forms of localized adiposity, improperly defined cellulite, in which the fat cells are perfectly normal and unaltered and the actual cellulite, identified by a pathological process. It is a disease that affects not only fat cells but also the cell-to-cell tissue and smaller blood vessels. Cronos Drainage is able to act on different targets:
- compactness and skin elasticity: silymarin, quercetin
- microcirculation activators and vessel protectors: quercetin
- activators of the lymphatic system and promoters of drainage for stimulation of diuresis: extracts of orthosiphon, dandelion, Polyporus
- adipocytic turnover stimulators: orthosiphon extract, chromium picolinate
- detoxifying, antioxidants: extracts of Silybum marianum and hawthorn
Polyporus umbellatus extract. In Traditional Chinese Medicine, Polyporus umbellatus is indicated for diseases resulting from humidity-stagnation and is therefore extensively used as a natural diuretic2,3. Polyporus increases the production of urine and stimulates the excretion of sodium and chlorine, without however a concomitant loss of potassium, which protects muscles and nerves, as occurs with the use of normal diuretics. The polysaccharide extracted from the mushroom has an immunostimulating action capable of increasing the production of immunoglobulins M (IgM) in vivo, i.e. molecules involved in the immune response of the human body4. Cronos DE:TOX contains 200 mg titrated to 30% in polysaccharides.
The Garcinia fruit is a rich source of hydroxycitric acid (HCA), the active agent that aids in weight loss by inhibiting fat production and suppressing appetite. Garcinia fruit extract in Cronos DE:TOX contains 60% HCA, which inhibits an enzyme that helps the body synthesize fat for storage in adipose tissue. HCA promotes energy, inhibits lipogenesis, lowers the production of cholesterol and fatty acids, increases the production of glycogen in the liver, suppresses appetite, and increases the body’s production of heat by activating the process of thermo genesis. (-)-HCA was shown to be a potent inhibitor of ATP citrate lyase. The inhibition of this reaction limits the availability of acetyl-CoA units required for fatty acid synthesis and lipogenesis during a lipogenic diet, that is, a diet high in carbohydrates.2-4
Orthosiphon: Orthosiphon stamineus or Java Tea is a plant of Malay origin present in the subtropical areas of south-east Asia and Latin America. Cronos DE:TOX formulation contains 100 mg of Orthosiphon dry extract per capsule, titrated in 0.2% sinensetin. It is known for its diuretic5 and purifying action and is widely used in all those cases in which it is desired to favor the elimination of water, nitrogenous waste and uric acid through the urine. It increases the volume of urine emitted in a moderate way, as happens on the other hand for one of the most well-known chemical diuretics, furosemide. 6. This plant also greatly stimulates the excretion of chlorine, with an efficacy equal to that of furosemide. The diuretic action of the plant is also due to a decrease in the retention of liquids by the colloids present in the tissues and in the blood, with a reduction in the strength of the bond existing between water and colloids, which is precisely one of the factors affecting production urine. Orthosiphon also has a mild cholesterol-lowering, hypotriglyceridemic, choleretic, cholagogue and hypoglycemic activity7. It is able to contribute to the reduction of cellulite and localized swellings as well as eliminate the toxins accumulated in the kidneys and liver. In addition, orthosiphon is suitable for those suffering from overweight problems or for those with high cholesterol levels.
Dandelion: Dandelion root has purifying properties, as it stimulates the biliary, hepatic and renal function, it activates the excretory organs (liver, kidney, skin) used for the transformation of toxins, in the most suitable form for their elimination (feces, urine, sweat). The main components of its phytocomplex are triterpene alcohols (tarasserol); sterols; vitamins (A, B, C, D); inulin, bitter principles (tarassacina), mineral salts that give the plant bitter-tonic and digestive properties. These substances also have purifying, anti-inflammatory and detoxifying properties against the liver: they promote the elimination of waste (sugars, triglycerides, cholesterol and uric acids, making the dandelion a hepatoprotective plant, indicated in case of hepatic insufficiency, jaundice and gallstones. It also stimulate diuresis favoring the elimination of excess liquids. Its intake is therefore indicated in case of water retention, cellulite and hypertension. Finally the dandelion is able to reactivate the immunological function and enhance the immune response of the lymphatic system8. Dandelion root could protect against oxidative stress linked atherosclerosis and decrease the atherogenic index9.
Hawthorn: Hawthorn or Crataegus oxyacantha is a very common shrub in the temperate zones of the northern hemisphere, of which berries and leaves are used; it contains crategolic acid, flavonic pigments, glycosides, anthocyanin-type pigments and terpene derivatives. The dry extract is used, titrated in vitexin, whose daily dose varies from 9 to 13 mg per kg of body weight, in two administrations. This plant has a marked affinity towards the heart, linked above all to flavonoids and proantocianidols. Hawthorn has cardiotonic, antiarrhythmic, coronary dilating, draining and hypotensive properties. In fact, the hawthorn decreases the phenomen related to sympathicotonia and at the same time increases the vagotonic state with consequent regularization of heart beats; its action is mainly due to the relaxation of the muscle fibrocells of the blood vessel wall. Hawthorn can effectively reduce the heart rate, the edema and the arterial pressure, also highlighting an action to strengthen the contractile force of the heart, with consequent improvement of water retention and diuresis. Very interesting is its ability to trap free radicals, thanks to which it strongly reduces the oxidation of LDLs, which tend to deposit in the wall of blood vessels after being oxidized. In this way it interferes with one of the fundamental events for the formation of atherosclerotic plaques in blood vessels. Its use is also desirable during low-calorie dietary regimes where depressive states of varying degrees are often determined, often affecting the success of the diet. In particular, during the diets of protein type, due to the competition of various factors, states of cardiac eretism can be produced, so it is advisable to supplement the diet with the Hawthorn. Numerous experiments and clinical studies have underlined cardiovascular efficacy of the plant through various mechanisms including positive inotropic and negative chronotropic effects, escalation in coronary blood flow and exercise tolerance, inhibition of the enzymes such as angiotensinconverting enzyme (ACE) and phosphodiesterase, anti-inflammatory and antihyperlipidemic effects, improving status of antioxidant enzymes, etc., which support its cardioactive efficacy10.
Hawthorn should be used with caution in patients with marked bradycardia (heart rate between 40 and 60 beats per minute) and / or disturbances in the conduction of the electrical stimulus in the heart. It can enhance the activity of inotropic-positive and hypotensive drugs and can interfere with digitalis therapies.
Silybum marianum is a herbaceous plant that grows in the Mediterranean basin in dry and uncultivated land. Contains flavolignans (derivatives of flavonoids) including silymarin. Is antioxidant, supports digestive and hepatic function and promotes the purifying functions of the body11,12.). Silymarin protects the liver from the free radical and increases protein synthesis. Silymarin has an antioxidant capacity 10 times greater than Vitamin E. It is an excellent systemic antioxidant capable of protecting skin cells, for healthier skin. Silymarin reduces oxidative stress and reduces the depletion of reduced glutathione which represents the most used antioxidant system by skin cells in maintaining the redox balance inside13.
Chromium: It is used in particular as chromium picolinate, a bright red coordination complex derived from chromium and picolinic acid; Food sources of chromium are very common foods, such as brewer’s yeast, meat, liver, cheeses, whole grains, mushrooms, prunes, asparagus, hazelnuts, wine and beer. Chromium is one of the 13 trace elements recognized as necessary for the human body. It is essential for carbohydrate metabolism; in particular it reduces insulin resistance, improving glucose metabolism and preventing hypoglycemia or diabetes. In diabetic patients, insulin requirements decrease and glucose tolerance increases14. Thanks to the role played in the formation of glycogen and in the transport of amino acids into muscle tissue, chromium would then increase muscle mass and sports performance. Chromium plays a role in protein synthesis through links with RNA molecules. However, in no study there was an increase in athletic ability that was not directly attributable to training. He is credited with the ability to lower cholesterol and triglyceride levels. In fact, the symptoms of chromium deficiency include high cholesterol and triglyceride levels. Although the precise mechanism of action is not yet well known, a chronic lack of chromium lowers the immune defenses15.
Quercetin: Flavonoid with a strong antioxidant and anti-inflammatory power, with anti-aging action. It counteracts premature skin aging by neutralizing free radicals, and protecting the dermal fibroblasts responsible for the synthesis of collagen and elastin. It plays an important role in the treatment of varicose veins, and symptoms of venous insufficiency, such as night cramps, pain, swelling and heaviness in the legs16. In an in vivo study using Wistar rats, quercetin-treated group showed less inflammatory cells, more fibroblast proliferation, increased microvessel density, better reepithelialization and more regular collagen deposition, as compared to control.17.
Alterations in the subcutaneous connective tissue
- wrinkles and stretch marks
Diseases that require an increase in draining activity
- localized and generalized edema
- food poisoning
- drug intoxication
Alterations in carbohydrate and lipid metabolism
- insulin resistance
- type 2 diabetes mellitus
- metabolic syndrome
Alterations in bone tissue