Cronos RE:FRESH, Biologically Active Food Supplement, is a herbal preparation with balancing and rejuvenating effects based on Triphala, a well-recognized and revered polyherbal Indian ayurvedic medical preparation, and Ganoderma lucidum extract. Useful in all cases of reduced dietary intake or increased need for useful components to improve gastrointestinal health and promotes efficient digestion, absorption, elimination, and rejuvenation.
A tablet of Cronos RE:FRESH is able to supply 750 mg of Triphala and 200 mg of Ganoderma lucidum. The particularly balanced formulation seems to play a positive role in the psycho-physical balance, with plants of proven activity and great tradition such as Triphala polyherbal and Ganoderma extract of improving the gastrointestinal health and to help in the case of constipation, abdominal pain, hyperacidity, and flatulence stimulating beneficial gut and skin bacteria and liver’s health.
Human skin is body’s vital organ constantly exposed to abiotic oxidative stress. This can have deleterious effects on skin such as darkening, skin damage, and aging. Skin is the primary barrier that protects the body from external aggressions. Skin aging is a complex biological process, categorized as chronological aging and photo-aging, and is affected by internal factors and external factors. Plant-derived products having skin-protective effects are well-known traditionally. RE:FRESH maintains proper secretions of the endocrinal system responsible for maintaining the appropriate homeostasis in the body and helping the vital physiological processes. Triphala, a formulation of three fruit products, is one of the most important rasayana drugs used in Ayurveda. Protective effects on facial skin was reported. In some studies Triphala increased collagen-I, involucrin and filaggrin synthesis and exhibited anti-tyrosinase and melanin inhibition properties in a dose-dependent manner1. Daily use of Triphala is supposed to promote normal appetite, good digestion, preventing senescence and increasing immunity, red blood cells and hemoglobin. Regular consumption of Triphala is proved to improve the skin complexion and to provide cosmetic benefit. The fungus Ganoderma lucidum is a famous herbal medicine in China, having featured in traditional Chinese medicine for >1,000 years2-4. Ganoderma polysaccharides (GL-PS), a major active ingredient in Ganoderma, confer immune regulation, antitumor effects and significant antioxidant effects.
Triphala is considered to be a tridoshic herbal preparation with balancing and rejuvenating effects. The name Triphala mentioned in the ancient Indian Ayurvedic texts, is a word in Sanskrit and means “three fruits”, each of which has already fabulous properties individually but which when combined take on exponential strength and curative characteristics: Emblica officinalis (Amalaki), Terminalia Chebula (Haritaki) and Terminalia Bellerica (Bibhitaki). The recipe for this traditional herbal supplement dates back thousands of years and is mentioned in traditional Indian texts. The formulation is used for colon cleansing and has been used for years to remove fecal matter from the body, preventing the formation of toxins, in particular Triphala inhibits intestinal candida and bacteria harmful to the body and promotes intestinal motility. It helps to stimulate the flow of bile and the contraction of smooth intestinal muscles that generate peristalsis, thus promoting intestinal evacuation and preventing bloating. Several studies have demonstrated the potential of Triphala as a therapeutic agent for weight loss and body fat reduction and as a hypoglycemic herbal medicine.
The major constituents of Triphala are the tannins, gallic acid, ellagic acid, and chebulinic acid, which are potent antioxidants that may account, at least in part, for the observed immunomodulatory activity of the formula5-7.Triphala also contains other bioactive compounds such as flavonoids (quercetin and luteolin), saponins, anthraquinones, amino acids, fatty acids, and various carbohydrates6. In addition, Triphala derived polyphenols such as chebulinic acid are also transformed by the human gut microbiota into bioactive metabolites, which have demonstrated potential in vitro to prevent oxidative damage2. Amalaki is an excellent source of Vitamin C, and is the most concentrated and absorbable source of the vitamin in the plant kingdom.
Ganoderma lucidum (Curtis) P. Karst. (lingzhi) is a medicinal mushroom with a wide variety of bioactive components, possessing nutraceutical and pharmaco- logical benefits . Popularly known as the “mushroom of immortality”, G. lucidum has been widely used in China for medicinal purposes for more than 2000 years. In traditional Chinese medicine it is used in the treatment of numerous diseases and as a metabolic activator, it contains active ingredients that can regulate the level of cholesterol, blood sugar and have a positive effect on cardiac arrhythmia8. Many scientific studies have highlighted the properties of Ganoderma, identifying, within it, a large number of beneficial substances for the body. Ganoderma contains numerous antioxidant active ingredients such as polyphenols, flavonoids, vitamin C, which neutralize the damage caused by free radicals, organic germanium which helps mitochondrial activity and cellular oxygenation, which means that it helps fight the effects of aging and enhance memory and learning. Again the triterpenes with adaptogenic but also hepatoprotective and hypocholesterolemic and antitumor action9,10. Beta-glucans, polysaccharides and glycoproteins with immunomodulating functions. In particular, the immunomodulatory protein called LZ-8 related to an ancestral protein of the immunoglobulin superfamily11. G. lucidum polysaccharides display regulatory abilities toward the immune system, resulting in antitumor and antioxidation effects12-14 Ganoderma extract has been demonstrated to protect murine skeletal muscles from oxidative stress following exhaustive exercise15, also regulates gene expression in aging skin cells and induces cytokine secretion, suggesting potential anti-aging effects15.