Cronos RE:NEW. A biologically active food supplement useful for promoting the body’s natural defenses and in all cases of increased need for useful components to improve your immune system. Cronos RE:NEW might directly stimulate the immune system and improve gastrointestinal health by restricting damage from infection or injury. Mushrooms act as a prebiotics to stimulate the growth of gut microbiota, conferring health benefits to the host.
Medicinal mushrooms as an attractive new source of natural compounds for pharmaceutical applications and can stimulate innate immune system. Cronos RE:NEW is a biologically active food supplement that contains the top mushrooms selected for their benefits for the skin, immune system and ability to fight inflammation, useful for promoting the body’s natural defenses and in all cases of increased need for useful components to improve your immune system.
Cronos RE:NEW contains the top mushrooms with immunomodulator activities: 6: 1 aqueous extract of Ganoderma lucidum, Maitake powder (Grifola frondosa), Shiitake powder (Lentinula edodes), Cordyceps powder (Cordyceps sinensis), Mushroom extract (Agaricus blazei) Pleurotus mycelium powder (Pleurotus ostreatus), Chaga powder (Inonotus obliquus) 5:1 aqueous extract of Poria cocos and Lion’s Mane powder (Hericium erinaceus).
Immunomodulators are key components in the modern health and wellness industries, reflecting the fact that the immune system is the first barrier for disease prevention. In any healthy organism, the immune system produces a wide range of immunomodulators to maintain homeostasis within the body. The mushrooms used in Cronos RE:NEW are among the most interesting natural sources of compounds for immune system stimulation and are central components of traditional medicine worldwide. They show greater diversity and possess unique bioactivity compared with other natural sources1. Cronos RE:NEW mushrooms display prebiotic effect through the modulation of gut microbiota. As immune modulators, they are useful in inflammatory skin conditions, such as atopic dermatitis and appear to be effective in reducing the incidence of atopic dermatitis, acne, to improve wound healing, and photoprotection.
Recently, the discovery or synthesis of new biologically active compounds has increasingly become difficult. At this time, interest in mushrooms as a potential source of bioactive compounds has occurred and much research investigating bioactivity has been investigated in the last two decades in detail. Up to date, lectins, polysaccharides, polysaccharide-protein complexes, polysaccharide-peptides, lanostane-type triterpenoids, phenolic, and flavonoid-structured compounds indicating anticancer, antioxidant, antitumour, antiviral, antibacterial, antifungal, anti-inflammatory, anti-imunomodulatory activities have been isolated from the mushroom species. Recently, mushrooms have been especially used as immunomodulators and antitumor agents. Medicinal mushrooms are the sources of polysaccharides that prevent the cancer and increase the strength of the immune system. Since the treatment of all types of cancers diseases has challenges, mushrooms may become very important source of drugs for modern medicine to find cures particularly for the cancer diseases2. Mushrooms contain chitin, a variety of other carbohydrate forms including, β and α-glucans, mannans, xylans, hemicellulose, and galactans. These components stimulate gut microbiota growth.
The use of mushrooms in traditional ancient therapies dates back at least to the Neolithic age. For millennia, mushrooms have been valued as edible and medical provisions for humankind. Mushrooms immunomodulators exhibit stimulating activities for both innate and adaptive immune systems. They proliferate and activate innate immune system components such as natural killer (NK) cells, neutrophils, and macrophages, and stimulate cytokines expression and secretion. These cytokines in turn activate adaptive immunity through the promotion of B cells for antibodies production and stimulation of T cell differentiation to T helper (Th) 1 and Th2 cells, which mediate cell and humoral immunities, respectively. Mushroom immunoceuticals act mainly by improving the host immune system. This process includes activation of dendritic cells, NK cells, T‐cells, macrophages, and production of cytokines. Several products, mainly polysaccharides (especially β‐glucans), were developed for clinical and commercial purposes. Moreover mushroom polysaccharides can contribute to the treatment of diseases including atopic dermatitis, allergic contact dermatitis, acne and photo aging.